Understanding thymus-independent antigen-induced reduction of thymus-dependent immune responses

Induction of Immunological Tolerance to a Thymus-dependent Antigen in the Absence of Thymus-derived Cells

Specific immunological unresponsiveness was induced using thymus-dependent antigens in congenitally athymic (nu/nu) mice, in which no T-cell function has been demonstrated. The tolerance was induced in vivo by the injection of 5-10 mg of either FGG or DNP-HGG. Spleen cells from treated mice were tested in vitro for the ability to mount thymus-independent immune responses against FGG in the pres...

Regulation of thymus-dependent and thymus-independent production of immunoglobulin G subclasses by Galpha12 and Galpha13

BACKGROUND A previous study from this laboratory showed that Galpha12 members participate in the production of inflammatory cytokines. In spite of the identification of B cell homeostasis responses regulated by Galpha13, the functional roles of Galpha12 members in the production of immunoglobulin (Ig) isotypes remained unknown. This study investigated whether Galpha12 members are involved in th...

Psychosocial factors are associated with the antibody response to both thymus-dependent and thymus-independent vaccines.

The present study examined the association between psychological stress, social support and antibody response to both thymus-dependent and thymus-independent vaccinations. Stressful life events in the previous year and customary social support were measured by standard questionnaires at baseline in 75 (41 females) healthy students. Antibody status was assessed at baseline, 4 and 18 weeks follow...

Mouse Thymus-independent and Thymus-derived Lymphoid Cells

The simultaneous use on mouse lymphoid suspensions of heterologous antisera directed against thymus-derived (T) cell mouse-specific lymphocyte antigen and brain-associated theta antigen (MSLA and BAtheta) or thymus-independent (B) cell mouse-specific bone marrow-derived lymphocyte antigen (MBLA) surface antigens allowed direct proof of the different specificity of these antisera by double immun...

Thymus - Independent Antigen - 2 Responses Cells and Negatively Regulates Is Specifically Expressed in Marginal Zone B